IRF8-dependent molecular complexes control the Th9 transcriptional program
نویسندگان
چکیده
منابع مشابه
STAT6-dependent regulation of Th9 development.
Th cell effector subsets develop in response to specific cytokine environments. The development of a particular cytokine-secreting pattern requires an integration of signals that may promote the development of opposing pathways. A recent example of this paradigm is the IL-9-secreting Th9 cell that develops in response to TGF-β and IL-4, cytokines that, in isolation, promote the development of i...
متن کاملTH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer
Naïve CD4+T cells differentiate into various T cell subsets depending on the specific cytokine environment. TH9 cells are less well-characterized than other T cell subsets, and factors that control their development and function have only recently been identified. It is now clear that TH9 cells play critical roles in immune-mediated diseases, including allergic airway, autoimmune and inflammato...
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Initiation of transcription by RNA polymerase II commonly requires the cooperation of two different sets of proteins, the basal transcription machinery and sequencespecific factors that bind to promoter/enhancer elements. How do the latter transcription factors relay their activating or repressing function to the basal transcription machinery? One way would be by direct interaction of the seque...
متن کاملTh9 cell development requires a BATF-regulated transcriptional network.
T helper 9 (Th9) cells are specialized for the production of IL-9, promote allergic inflammation in mice, and are associated with allergic disease in humans. It has not been determined whether Th9 cells express a characteristic transcriptional signature. In this study, we performed microarray analysis to identify genes enriched in Th9 cells compared with other Th subsets. This analysis defined ...
متن کاملDisassembly of transcriptional regulatory complexes by molecular chaperones.
Many biological processes are initiated by cooperative assembly of large multicomponent complexes; however, mechanisms for modulating or terminating the actions of these complexes are not well understood. For example, hormone-bound intracellular receptors (IRs) nucleate formation of transcriptional regulatory complexes whose actions cease promptly upon hormone withdrawal. Here, we show that the...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01070-w